Domenic Burger

About

Domenic joined the LBEM in March 2021 after previously doing his Masters in the former lab of Prof. Stahlberg. During his master studies he started working on the three-dimensional structural organisation of various alpha-synuclein fibrils which carried over into his PhD-thesis. Next to this he is establishing a workflow for cryo correlative light and electron microscopy to directly investigate the fibril conformation in brain tissue.

Current Project

Structure determination of alpha-synuclein fibrils

Fibril investigation in MSA brain

Biography

April 2020MSc in Molecular Biology, University of Basel, Switzerland
January 2019BSc in Biology, Major in Molecular Biology, University of Basel, Switzerland

Publications

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Ultrastructural diversity of alpha-Synuclein pathology in the post-mortem brain of Parkinson patients: implications for Lewy Body formation

Lewis, A., Van Den Heuvel, L., Di Fabrizio, M., Burger, D., Huisman, E., Bol, J.G.J.M., van de Berg, W.D.J., Stahlberg, H.

(submitted), (2024)

5

1.9 Å structure of synthetic alpha-synuclein fibrils ...

Burger, D., Kashyrina, M., Lewis, A., De Nuccio, F., Mohammed, I., de La Seiglière, H., Van Den Heuvel, L., Verchère, J., Feuillie, C., Berbon, M., Arotçarena, M.-L., Retailleau, A., Bezard, E., Laferrière, F., Loquet, A., Bousset, L., Baron, T., Lofrumento, D. D., De Giorgi, F., Stahlberg, H., Ichas, F.

(submitted), (2024)

4

A versatile correlative light and electron microscopy protocol for human brain and other biological models

Shafiei, N., Stähli, D., Burger, D., Di Fabrizio, M., Van Den Heuvel, L., Daraspe, J., Böing, C., Shahmoradian, S., van de Berg, W.D.J., Genoud, C., Stahlberg, H., Lewis, A.

(submitted), (2024)

3

Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy

Böing, C., Di Fabrizio, M., Burger, D., Bol, J.G.J., Huisman, E., Rozemuller, A.J.M., van de Berg, W.D.J., Stahlberg, H., Lewis, A.

Brain awae137(in press), (2024)

DOI: DOI

2

Cryo-EM structure of alpha-synuclein fibrils amplified by PMCA from PD and MSA patient brains

Burger, D., Fenyi, A., Bousset, L., Stahlberg, H., Melki, R.

bioRxiv 2021.07.08.451588, (2022)

DOI: DOI

1