Domenic joined the LBEM in March 2021 after previously doing his Masters in the former lab of Prof. Stahlberg. During his master studies he started working on the three-dimensional structural organisation of various alpha-synuclein fibrils which carried over into his PhD-thesis. Next to this he is establishing a workflow for cryo correlative light and electron microscopy to directly investigate the fibril conformation in brain tissue.
Structure determination of alpha-synuclein fibrils
Fibril investigation in MSA brain
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Publications
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1.9 Å structure of synthetic alpha-synuclein fibrils ... (submitted), (2024)
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(submitted), (2024)
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(submitted), (2024)
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Brain 147(11), 3727-3741 (2024)
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Cryo-EM structure of alpha-synuclein fibrils amplified by PMCA from PD and MSA patient brains bioRxiv 2021.07.08.451588, (2022)
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