Electron microscopy in Life Sciences can be grouped into several categories:
- Transmission Electron Microscopy (TEM) can be used with room temperature samples to perform first low-resolution studies of the samples.
- Cryo-Electron Microscopy (Cryo-EM) can be used with frozen samples to obtain atomic resolution structures of proteins.
- Cryo-Electron Tomography (Cryo-ET) provides 3D volume analysis of sections of cells or organelles or bacteria, and cryo-ET can also be used on isolated particles.
- Correlative Light and Electron Microscopy (CLEM) is a method that combines the analytic possibilities of fluorescense light microscopy with the high-resolution structural analysis of the electron microscope.