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A versatile correlative light and electron microscopy protocol for human brain and other biological models

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Structural basis of SIRT7 nucleosome engagement and substrate specificity

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Mouse alpha-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases

Sokratian, A., Zhou, Y., Tatli, M., Burbidge, K.J., Xu, E., Viverette, E., Duda, A.M., Yuan, Y., Strader, S., Patel, N., Shiell, N., Malankhanova, T., Chen, O., Mazzulli, J.R., Perera, L., Stahlberg, H., Borgnia, M., Bartesaghi, B., Lashuel, H.L., West, A.B.

Science Advances 10(44), eadq3539 (2024)

Ultrastructural diversity of alpha-Synuclein pathology in the post-mortem brain of Parkinson patients: implications for Lewy Body formation

Lewis, A., Van Den Heuvel, L., Di Fabrizio, M., Burger, D., Huisman, E., Bol, J.G.J.M., van de Berg, W.D.J., Stahlberg, H.

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Biased agonism of carvedilol in the beta1-adrenergic receptor is governed by conformational exclusion

Abiko, L.A., Petrovic, I., Tatli, M., Desai, S., Stahlberg, H., Spang, A., Grzesiek, S.

(submitted), (2024)

Identification of a binding site for small molecule inhibitors targeting human TRPM4

Ekundayo, B., Aruliampalam, P., Hämmerli, A.-F., Guichard, S., Boukenna, M., Rougier, J.-S., Abriel, H., Stahlberg, H., Ni, D.

Nature Communications (In press), (2024)

Modulation of ABCG2 transporter activity by Ko143 derivatives

Yu, Q., Dehghanighahnaviyeh, S., Rasouli, A., Sadurni, A., Kowal, J., Bang-Sørensen, R., Wen, P.-C., Zechner, M., Irobalieva, R., Ni, D., Stahlberg, H., Altmann, K.-H., Tajkhorshid, E., Locher, K.,

ACS Chem. Biol. 19(11), 2304-2313 (2024)

Joint ptychographic tomography of frozen hydrated proteins

Varnavides, G., Yu, Y., Küçükoglu, B., Ribet, S., Scott, M., Stahlberg, H., Ophus, C.

BIO Web Conf. 129(11005), 2 (2024)

Automated fiducial-based alignment of cryo-electron tomography tilt series in Dynamo

Coray, R., Pérez Navarro, P., Scaramuzza, S., Stahlberg, H., Castano-Diez, D.

Structure 32(10), 1808-1819.e4 (2024)

Low-dose cryo-electron ptychography of proteins at sub-nanometer resolution

Küçükoglu, B., Mohammed, I., Guerrero Ferreira, R., Kube, M., Radecke, J., Ribet, S.M., Varnavides, G., Leidl, M.L., Lau, K., Nazarov, S., Myasnikov, A., Sachse, C., Müller-Caspary, K., Ophus, C., Stahlberg, H.

Nature Communications 15, 8062 (2024)

Cryo-electron microscopy in color

Stahlberg, H.

Nature Methods , October (2024)

Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy

Böing, C., Di Fabrizio, M., Burger, D., Bol, J.G.J., Huisman, E., Rozemuller, A.J.M., van de Berg, W.D.J., Stahlberg, H., Lewis, A.

Brain 147(11), 3727-3741 (2024)

Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of ?-synuclein inclusions

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Neuron 112(17), 2886-2909 (2024)

Progress in Physics: Structural analysis of proteins by cryo-electron ptychography

Küçükoglu, B., Kube, M., Stahlberg, H.

SPS Communications 73, 34-37 (2024)

Hierarchical protofilament intertwining rules the formation of mixed-curvature amyloid polymorphs

Zhou, J., Assenza, S., Tatli, M., Tian, J., Ilie, I.M., Starostin, E.L., Caflisch, A., Knowles, T.P.J., Dietler, G., Ruggeri, F.S., Stahlberg, H., Sekatski, S., Mezzenga, R.

Advanced Science 2402740, 1-12 (2024)

Structure-function analysis of the cyclic beta-1,2-glucan synthase from Agrobacterium tumefaciens

Sedzicki, J., Ni, D., Lehmann, F., Stahlberg, H., Dehio, C.

Nature Communications 15(1), 1844 (2024)

Computational drug development for membrane protein targets

Li, H., Sun, X., Cui, W., Xu, M., Dong, J., Ekundayo, B., Ni, D., Rao, Z., Stahlberg, H., Yuan, S., Vogel, H.

Nature Biotechnology 42(2), 229-242 (2024)

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

Liu, H., Irobalieva, R., Kowal, J., Ni, D., Nosol, K., Bang-Sorensen, R., Lancien, L., Stahlberg, H., Stieger, B., Locher, K.

Nature Communications 14(7296), 1-12 (2023)

Structure of a membrane-bound menaquinol:organohalide oxidoreductase

Cimmino, L., Duarte, A., Ni, D., Ekundayo, B., Pereira, I.A.C., Stahlberg, H., Holliger, C., Maillard, J.

Nature Communications 14(7038), (2023)

Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

Tan, C.C.S., Trew, J., Peacock, T.P., Mok, K.Y., Hart, C., Lau, K., Ni, D., ..., Balloux, F., Savolainen, V.

Nature Communications 14(3322), (2023)

Structural basis of the allosteric inhibition of human ABCG2 by nanobodies

Irobalieva, R.N., Manolaridis, I., Jackson, S.M., Ni, D., Pardon, E., Stahlberg, H., Steyaert, J., Locher, K.P.

J. Mol. Biol. 435(19), 168234 (2023)

Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates

Limorenko, G., Tatli, M., Kolla, R., Nazarov, S., Weil, M.T., Schöndorf, D.C., Geist, D., Reinhardt, P., Ehrnhoefer, D.E., Stahlberg, H., Gasparini, L., Lashuel, H.A.

Nature Communications 14(3939), (2023)

Machine Learning in Protein Science De Novo Design of Site-Specific Protein Binders Using Surface Fingerprints

Van Hall-Beauvais, A., Gainza, P., Wehrle, S., Scheck, A., Marchand, A., Harteveld, Z., Goverde, C., Ni, D., Shuguang, T., Turelli, P., Trono, D., Stahlberg, H., Gao, G., Bronstein, M., Correia, B.

Protein Science 32(1), S106 (2023)

Activation mechanism of a short argonaute-TIR antiviral defense system

Ni, D., Lu, X., Stahlberg, H., Ekundayo, B.

Science Advances 9(29), eadh9002 (2023)

De novo design of protein interactions with learned surface fingerprints

Gainza, P., Wehrle, S., ..., Ni, D., ..., Fierz, B., Trono, D., Stahlberg, H., Bronstein, M., Correia, B.E.

Nature 617(5759), 176-184 (2023)

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

Ni, D., Turelli, P., Beckert, B., Nazarov, S., Uchikawa, E., Myasnikov, A., Pojer, F., Trono, D., Stahlberg, H., Lau, K.

PLoS Pathogens 19(4), e1011206 (2023)

Structural insights into the regulation of Cas7-11 by TPR-CHAT

Ekundayo, B., Torre, D., Beckert, B., Nazarov, S., Myasnikov, A., Stahlberg, H., Ni, D.

Nature Struct. Mol. Biol. 30(2), 135-139 (2023)

Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools

Hu, C., Ni, D., Nam, K.H., Majumdar, S., McLean, J., Stahlberg, H., Terns, M.P., Ke, A.

Molecular Cell 82(15), 2754-2768 (2022)

Lossless cryo-grid preparation stage for high-resolution electron microscopy

Arnold, S., Braun, T., Stahlberg, H.

US Patent 11,442,074, (2022)

Cryo-EM structure of native human thyroglobulin

Adaixo, R., Steiner, E.M., Righetto, R., Schmidt, A., Stahlberg, H., Taylor, N.

Nature Comm. 13(1), 61 (2022)

Cryo-EM structure of alpha-synuclein fibrils amplified by PMCA from PD and MSA patient brains

Burger, D., Fenyi, A., Bousset, L., Stahlberg, H., Melki, R.

bioRxiv 2021.07.08.451588, (2022)

Mechanism of cyclic Beta-glucan export by ABC transporter Cgt of Brucella

Sedzicki, J., Ni, D., Lehmann, F., Wu, N., Zenobi, R., Jung, S., Stahlberg, H., Dehio, C.

Nature Struct. Mol. Biol. 29(12), 1170-1177 (2022)

2.4 Å structure of the double ring Gemmatimonas phototrophica photosystem

Qian, P., Gardiner, A.T., Simova, I., Naydenova, K., Croll, T.I., Jackson, P.J., Nupur, Kloz, M., Cubáková, P., Kuzma, M., Zeng, Y., Castro-Hartmann. P., Knippenberg, B.v., Goldie, K., Kaftan, D., et al., Stahlberg, H., Sobotka, R., Russo, C.J., Polivka, T., Hunter, C.N., Koblizek, M.

Science Advances 8(7), eabk3139 (2022)

Trans-seeding of Alzheimer’s-related tau protein by a yeast prion

Flach, M., Leu, C., Martinisi, A., Skachokova, Z., Frank, S., Tolnay, M., Stahlberg, H., Winkler, D.

Alzheimer's Dementia 18(12), 2481-2492 (2022)

Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

Fenwick, C., Turelli, P., Ni, D., Perez, L., Lau, K., ..., Leyssen, P., Lévy, Y., Pojer, F., Stahlberg, H., LeGrand, R., Trono, D., Pantaleo, G.

Nature Microbiology 7(9), 1376-1389 (2022)

Structural analysis of the Spike of the Omicron SARS-COV-2 variant by cryo-EM and implications for immune evasion

Ni, D., Lau, K., Turelli, P., Raclot, C., Beckert, B., Nazarov, S., Pojer, F., Myasnikov, A., Stahlberg, H., Trono, D.

bioRxiv 2021.12.27.474250, (2022)

Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation

Botte, M., Ni, D., Schenck, S., Zimmermann, I., Chami, M., Bocquet, N., Egloff, P., Bucher, D., Trabuco, M., Cheng, R.K.Y., Brunner, J.D., Seeger, M.A., Stahlberg, H., Hennig, M.

Nature Communications 13(1), 1826 (2022)

Structural and molecular determinants for the interaction of ExbB from Serratia marcescens and HasB, a TonB paralog

Biou, V., Adaixo, R., Chami, M., Coureux. P., Laurent B., Ntsogo, Y., Cardoso de Amorim, G., Izadi-Pruneyre, N., Malosse, C., Chamot-Rooke, J., Stahlberg, H., Delepelaire, P.

Commun. Biol. 5(1), 355 (2022)

FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade

De Rossi, P., Lewis, A., Furrer, J., De Vos, L., Demeter, T., Zbinden, A., Zhong, W., Wiersma, V.I., Scialo, C., Weber, J., Guo, Z., Scaramuzza, S., Di Fabrizio, M., Böing, C., Castano-Diez, D., Al-Amoudi, A., Pérez-Berlanga, M., Lashley, T., Stahlberg, H., Polymenidou, M.

EMBO Rep. 22(12), e53877 (2021)

Structural strains of misfolded tau protein define different diseases

Stahlberg, H., Riek, R.

Nature 598(7880), 264-265 (2021)

Identification of a Dps contamination in Mitomycin-C-induced expression of Colicin Ia

Pipercevic, J., Jakob, R.P., Righetto, R., Goldie, K., Stahlberg, H., Maier, T., Hiller, S.

Biochim. Biophys. Acta Biomembr. 1863(7), 183607 (2021)

Structural basis of drug recognition by the multidrug transporter ABCG2

Kowal, J., Ni, D., Jackson, S.M., Manolaridis, I., Stahlberg, H., Locher, K.P.

J. Mol. Biol. 433(13), 166980 (2021)

Structures of ABCG2 under turnover conditions reveal a key step in drug transport mechanism

Yu, Q., Ni, D., Kowal, J., Manolaridis, I., Jackson, S.M., Stahlberg, H., Locher, K.P.

Nature Comm. 12(4376), (2021)

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

Isaikina, P., Tsai, C.-J., Dietz, N.B., Pamula, F., Grahl, A., Goldie, K., Guixa-Gonzalez, R., Schertler, G.F.X., Hartley, O., Stahlberg, H., Maier, T., Deupi, X., Grzesiek, S.

Science Adv. 7:eabg8685, (2021)

Coordination-Driven Monolayer-to-Bilayer Transition in Two-Dimensional Metal-Organic Networks

Moradi, M., Opara, N., Housecroft, C., Tulli, L., Stahlberg, H., Jung, T., Shahgaldian, P.

J. Phys. Chem. 125(16), 4204-4211 (2021)

Single particle analysis for high resolution 2D electron crystallography

Righetto, R., Stahlberg, H.

Methods in Mol. Biology. 2215, 267-284 (2021)

Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation

Botte, M., Ulrich, A.K.C., Adaixo, R., Gnutt, D., Brockmann, A., Bucher, D., Chami, M., Bocquet, N., Ebbinghaus-Kintscher, U., Puetter, V., Becker, A., Egner, U., Stahlberg, H., Hennig, M., Holton, S.J.

bioRxiv , 2020.10.13.334797 (2020)

Structural investigation of ACE2 dependent disassembly of the trimeric SARS-CoV-2 Spike glycoprotein

Ni, D., Lau, K., Lehmann, F., Fränkl, A., Hacker, D., Pojer, F., Stahlberg, H.

bioRxiv 2020.10.12.336016, (2020)

Alterations in sub-axonal architecture between normal aging and Parkinson's diseased human brains using label-free cryogenic X-ray nanotomography

Tran, H.T., Tsai, E.H.R., Lewis, A., Moors, T., Bol, J.G.J.M., Rostami, I., Diaz, A., Joker, A.J., Guizar-Sicairos, M., Raabe, J., Stahlberg, H., van de Berg, W.D.J., Holler, M., Shahmoradian, S.

Frontiers in Neuroscience 14(570019), (2020)

Architecture of the centriole cartwheel-containing region revealed by cryo-electron tomography

Klena, N., Le Guennec, M., Tassin, A.M., Van den Hoek, H., Erdmann, P.S., Schaffer, M., Geimer, S., Aeschlimann. G., Kovacik, L., Goldie, K., Sadian, Y., Stahlberg, H., Engel, B.D., Hamel, V., Guichard, P.

EMBO J. e106246, 1-7 (2020)

Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody

Sears, A.E., Albiez, S., Gulati, S., Wang, B., Kiser, P., Kovacik, L., Engel, A., Stahlberg, H., Palczewski, K.

FASEB J. 34(10), 13918-13934 (2020)

Structural basis of Focal Adhesion Kinase activation on lipid membranes

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EMBO J. 39(e104743), (2020)

Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody

M. Geiger, K.-G. Stubenrauch, J. Sam, W.F. Richter, G. Jordan, J. Eckmann, C. Hage, V. Nicolini, A. Freimoser-Grundschober, M. Ritter, M.E. Lauer, Stahlberg, H., Ringler, P., J. Patel, E. Sullivan, S. Grau-Richards, S. Endres, S. Kobold, P. Umaña, P. Brünker, C. Klein

Nature Commun. 11(1), 3196 (2020)

The Contorsbody, an antibody format for agonism: design, structure, and function

Georges, G.J., Dengl, S., Bujotzek, A., Hesse, F., Fischer, J.A.a., Gärtner, A., Benz, J., Lauer, M.E., Ringler, P., Stahlberg, H., Plath, F., Brinkmann, U., Imhof-Jung, S.

Comp. Struct. Biol. J. 18, 1210-1220 (2020)

High-resolution cryo-EM structure of urease from the pathogen Yersinia enterocolitica

Righetto, R., Anton, L., Rima, L., Jakob, R.P., Zivanov, J., Mahi, M.-A., Ringler, P., Schwede, T., Maier, T., Stahlberg, H.

Nature Commun. 11, 5101 (2020)

Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice

Ruskamo, S., Krokengen, O.C., Kowal, J., Nieminen, T., Lehtimäki, M., Raasakka, A., Dandey, V., Vattulainen, I., Stahlberg, H., Kursula, P.

J. Biol. Chemistry 295(26), 8692-8705 (2020)

New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy

Guerrero Ferreira, R., Kovacik, L., Ni, D., Stahlberg, H.

Current Opinion in Neurobiology 61, 89-95 (2020)

Grayscale e-beam lithography: Effects of a delayed development for well-controlled 3D patterning

Mortelmans, T., Kazasiz, D., Guzenko, V.A., Padeste, C., Braun, T., Stahlberg, H., Li, X., Ekinci, Y.

Microelectronic Engineering 225, 111272 (2020)

A helical inner scaffold provides a structural basis for centriole cohesion

Le Guennec, M., Klena, N., Gambarotto, D., Laporte, M.H., Tassin, A.M., van den Hoek, H., Erdmann, P.S., Schaffer, M., Kovacik, L., Borgers, S., Goldie, K., Stahlberg, H., Bornens, M., Azimzadeh, J., Engel, B.D., Hamel, V., Guichard, P.

Science Advances 6(7), eaaz4137 (2020)

Inner-membrane GspF of the bacterial type II secretion system is a dimeric adaptor mediating pseudopilus biogenesis

Van Putte, W., De Vos, T., Vanden Broeck, W., Stahlberg, H., Kudryashev, M., Savvides, S.N.

bioRxiv 435982, (2020)

DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity

Sustmann, C., Dickopf, S., Regula, J.T., Kettenberger, H., Mølhøj, M., Gassner, C., Weininger, D., Fenn, S., Manigold, T., Kling, L., Künkele, K.P., Schwaiger, M., Bossenmaier, B., Griese, J.J., Hopfner, K.P., Graff, A., Stahlberg, H., Ringler, P., Lauer, M.E., Brinkmann, U., Schaefer, W., Klein, C.

MAbs 11(8), 1402-1414 (2019)

Diverse roles of TssA-like proteins in the assembly of bacterial type VI secretion systems

Schneider, J.P., Nazarov, S., Liuzzo, M., Ringel, P.D., Stahlberg, H., Basler, M.

EMBO J. 38: e100825, 1-17 (2019)

Two new polymorphic structures of alpha-synuclein solved by cryo-electron microscopy

Guerrero Ferreira, R., Taylor, N., Arteni, A.-A., Kumari, P., Mona, D., Ringler, P., Britschgi, M., Lauer, M.E., Verasdock, J., Riek, R., Melki, R., Meier, B.H., Böckmann, A., Bousset, L., Stahlberg, H.

eLife 8:e48907, (2019)

Cryo-EM structure of the rhodopsin-G-alpha-i-beta-gamma complex reveals binding of the rhodopsin C-terminal tail to the G-beta subunit

Tsai, C.J., Marino, J., Adaixo, R., Pamula, F., Muehle, J., Maeda, S., Flock, T., Taylor, N., Mohammed, I., Matile, H., Dawson, R.J.P., Deupi, X., Stahlberg, H., Schertler, G.F.X.

eLife 8;e46041, (2019)

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes

Shahmoradian, S., Lewis, A., Genoud, C., Graff, A., Pérez Navarro, P., Goldie, K., Sütterlin, R., Castano-Diez, D., Ingrassia, A., Rozemuller, A.J.M., Paepe, A.D., Erny, J.Staempfli, A., Hoernschemeyer, J., Niedieker, D., El-Mashtoly, S.F., Gerwert, K., Bohrmann, B., Britschgi, M., Stahlberg, H., van de Berg, W.D.J., Lauer, M.E.

Nature Neuroscience 22, 1099-1109 (2019)

‘Differential visual proteomics’: Enabling the proteome-wide comparison of protein structures of single-cells

Syntychaki, A., Rima, L., Schmidli, C., Stohler, T., Bieri, A., Sütterlin, R., Stahlberg, H., Castano-Diez, D., Braun, T.

J. of Proteome Research 18(9), 3521-3531 (2019)

Imaging of post-mortem human brain tissue using electron and X-ray microscopy

Lewis, A., Genoud, C., Pont, M., van de Berg, W.D.J., Frank, S., Stahlberg, H., Shahmoradian, S., Al-Amoudi, A.

Current Opinion Structural Biology 58, 138-148 (2019)

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy

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Science Translational Medicine 11(496), 1-12 (2019)

Microfluidic protein isolation and sample preparation for high resolution cryo-EM

Schmidli, C., Albiez, S., Rima, L., Righetto, R., Mohammed, I., Oliva, P., Kovacik, L., Stahlberg, H., Braun, T.

PNAS 116(30), 15007-15012 (2019)

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin

Piper, S., Brillault, L., Rothnagel, R., Croll, T., Box, J., Chassagnon, I., Scherer, S., Goldie, K., Jones, S., Schepers, F., Hartley-Tassell, L., Ve, T., Busby, J., Dalziel, J., Lott, S., Hankamer, B., Stahlberg, H., Hurst, M., Landsberg, M

Nature Communications 10(1), 1952 (2019)

Array based real-time measurement of fluid viscosities and mass-densities to monitor biological filament formation

Oliva, P., Bircher, B., Schönenberger, C.-A., Braun, T.

Lab on a Chip 19(7), 1305-1314 (2019)

Deuterium induces a distinctive Escherichia coli proteome that correlates with the reduction in growth rate.

Opitz, C., Ahrne, E., Goldie, K., Schmidt, A., Grzesiek, S

J. Biol. Chem. 294(7), 2279-2292 (2019)

Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases

Gulati, S., Palczewski, K., Engel, A., Stahlberg, H., Kovacik, L.

Science Advances 5(2), eaav4322 (2019)

Retrieving high-resolution information from disordered 2D crystals by single particle cryo-EM

Righetto, R., Biyani, N., Kowal, J., Chami, M., Stahlberg, H.

Nature Communications 10(1), 1722 (2019)

Molecular structure and function of myelin protein P0 in membrane stacking

Raasakka, A., Ruskamo, S., Kowal, J., Han, H., Baumann, A., Myllykoski, M., Fasano, A., Rossano, R., Riccio, P., Buerck, J., Ulrich, A.S., Stahlberg, H., Kursula, P.

Scientific Reports 9(462), (2019)

TDP-43 extracted from FTLD patient brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates

Laferriere, F., Maniecka, Perez-Berlanga, Hruska-Plochan, Gilhespy, Hock, Wagner, Afroz, Boersema, Barmettler, Foti, Asi, Isaacs, Al-Amoudi, A., Lewis, A., Stahlberg, H., Ravits, De Giorgi, Ichas, Bezard, Picotti, P., Lashley, T., Polymenidou, M.

Nature Neuroscience 22, 65-77 (2019)

Part 2: Coping with Biology

Benjamin Stecher. (Images:, Lewis, A., Shahmoradian, S., Stahlberg, H., )

Tomorrow Edition (an online blog by Benjamin Stecher about his journey in Parkinson's disease), (2018)

Rapid Structure Determination of Microcrystalline Molecular Compounds Using Electron Diffraction.

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Merging of image data in electron crystallography

Arheit, M., Castano-Diez, D., Thierry, R., Abeyrathne, P., Gipson, B., Stahlberg, H.

Methods Mol Biol 955, 195-209 (2013)

Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism

Degiacomi, M. T., Iacovache, I., Pernot, L., Chami, M., Kudryashev, M., Stahlberg, H., van der Goot, F. G., Dal Peraro, M.

Nat Chem Biol 9(10), 623-9 (2013)

The application of graphene as a sample support in transmission electron microscopy

Pantelic, R., Meyer, J.C., Kaiser, U., Stahlberg, H.

Solid State Commun 152(15), 1375-1382 (2012)

Analysis of 2-D crystals of membrane proteins by electron microscopy

Abeyrathne, P., Arheit, M., Kebbel, F., Castano-Diez, D., Goldie, K., Chami, M., Relault, L., Kühlbrandt, W., Stahlberg, H.

Comprehensive Biophysics 1, 277-310 (2012)

Projection structure of the secondary citrate/sodium symporter CitS at 6 Å resolution by electron crystallography

Kebbel, F., Kurz, M., Grütter, M. G., Stahlberg, H.

J Mol Biol 418(42006), 117-26 (2012)

RNAi screening reveals proteasome- and Cullin3-dependent stages in vaccinia virus infection

Mercer, J., Snijder, B., Sacher, R., Burkard, C., Bleck, C. K., Stahlberg, H., Pelkmans, L., Helenius, A.

Cell Rep 2(4), 1036-47 (2012)

Assessing the benefits of focal pair cryo-electron tomography

Kudryashev, M., Stahlberg, H., Castano-Diez, D.

J Struct Biol 178(2), 88-97 (2012)

Structural basis for chirality and directional motility of Plasmodium sporozoites

Kudryashev, M., Munter, S., Lemgruber, L., Montagna, G., Stahlberg, H., Matuschewski, K., Meissner, M., Cyrklaff, M., Frischknecht, F.

Cell Microbiol 14(11), 1757-68 (2012)

Structure and function of purified monoclonal antibody dimers induced by different stress conditions

Paul, R., Graff, A., Stahlberg, H., Lauer, M. E., Rufer, A. C., Beck, H., Briguet, A., Schnaible, V., Buckel, T., Boeckle, S.

Pharm Res 29(8), 2047-59 (2012)

Characterization of the motion of membrane proteins using high-speed atomic force microscopy

Casuso, I., Khao, J., Chami, M., Paul-Gilloteaux, P., Husain, M., Duneau, J. P., Stahlberg, H., Sturgis, J. N., Scheuring, S.

Nat Nanotechnol 7(8), 525-9 (2012)

Connecting micro-fluidics to electron microscopy

Kemmerling, Simon, Ziegler, J., Schweighauser, G., Arnold, S., Giss, D., Müller, S., Ringler, P., Goldie, K., Goedecke, N., Hierlemann, A., Stahlberg, H., Engel, A., Braun, T.

J Struct Biol 177(1), 128-134 (2012)

Dynamo: a flexible, user-friendly development tool for subtomogram averaging of cryo-EM data in high-performance computing environments

Castano-Diez, D., Kudryashev, M., Arheit, M., Stahlberg, H.

J Struct Biol 178(2), 139-51 (2012)

Ionic liquids as matrices in microfluidic sample deposition for high-mass matrix- assisted laser desorption/ionization mass spectrometry

Weidmann, S., Kemmerling, S., Madler, S., Stahlberg, H., Braun, T., Zenobi, R.

Eur J Mass Spectrom (Chichester, Eng) 18(3), 279-86 (2012)

Limiting factors in single particle cryo electron tomography

Kudryashev, M., Castano-Diez, D., Stahlberg, H.

Comput Struct Biotechnol J 1, e201207002 (2012)

Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair

Schwartz, E. K., Wright, W. D., Ehmsen, K. T., Evans, J. E., Stahlberg, H., Heyer, W. D.

Mol Cell Biol 32(15), 3065-80 (2012)

Oxidative doping renders graphene hydrophilic, facilitating its use as a support in biological TEM

Pantelic, R., Suk, J. W., Hao, Y., Ruoff, R. S., Stahlberg, H.

Nano Lett 11(10), 4319-23 (2011)

Polymer-based cell-free expression of ligand-binding family B G-protein coupled receptors without detergents

Klammt, C., Perrin, M. H., Maslennikov, I., Renault, L., Krupa, M., Kwiatkowski, W., Stahlberg, H., Vale, W., Choe, S.

Protein Sci 20(6), 1030-41 (2011)

Rad51 paralogues Rad55-Rad57 balance the antirecombinase Srs2 in Rad51 filament formation

Liu, J., Renault, L., Veaute, X., Fabre, F., Stahlberg, H., Heyer, W. D.

Nature 479(7372), 245-8 (2011)

Automatic recovery of missing amplitudes and phases in tilt-limited electron crystallography of two-dimensional crystals

Gipson, B., Masiel, D. J., Browning, N. D., Spence, J., Mitsuoka, K., Stahlberg, H.

Phys Rev E Stat Nonlin Soft Matter Phys 84(1 Pt 1), 11916 (2011)

Graphene: Substrate preparation and introduction

Pantelic, R., Suk, J. W., Magnuson, C. W., Meyer, J. C., Wachsmuth, P., Kaiser, U., Ruoff, R. S., Stahlberg, H.

J Struct Biol 174(1), 234-8 (2011)

Interaction of complexes I, III, and IV within the bovine respirasome by single particle cryo electron tomography

Dudkina, N. V., Kudryashev, M., Stahlberg, H., Boekema, E. J.

Proc Natl Acad Sci U S A 108(37), 15196-200 (2011)

3D reconstruction from 2D crystal image and diffraction data

Schenk, A. D., Castano-Diez, D., Gipson, B., Arheit, M., Zeng, X., Stahlberg, H.

Methods Enzymol 482, 101-29 (2010)

Preparation of 2D crystals of membrane proteins for high-resolution electron crystallography data collection

Abeyrathne, P., Chami, M., Pantelic, R., Goldie, K., Stahlberg, H.

Method Enzymol 481, 25-43 (2010)

High-resolution low-dose scanning transmission electron microscopy

Buban, J. P., Ramasse, Q., Gipson, B., Browning, N. D., Stahlberg, H.

J Electron Microsc (Tokyo) 59(2), 103-12 (2010)

Structural variability of edge dislocations in a SrTiO3 low-angle [001] tilt grain boundary

Buban, J.P., Chi, M., Masiel, D.J., Bradley, J.P., Jiang, B., Stahlberg, H., Browning, N.D.

J Mater Res 24, 2191-2199 (2009)

2007 annual progress report synopsis of the Center for Structures of Membrane Proteins

Stroud, R. M., Choe, S., Holton, J., Kaback, H. R., Kwiatkowski, W., Minor, D. L., Riek, R., Sali, A., Stahlberg, H., Harries, W.

J Struct Funct Genomics 10(2), 193-208 (2009)

Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion

DeVay, R. M., Dominguez-Ramirez, L., Lackner, L. L., Hoppins, S., Stahlberg, H., Nunnari, J.

J Cell Biol 186(6), 793-803 (2009)

Crystal structures of Limulus SAP-like pentraxin reveal two molecular aggregations

Shrive, A. K., Burns, I., Chou, H. T., Stahlberg, H., Armstrong, P. B., Greenhough, T. J.

J Mol Biol 386(5), 1240-54 (2009)

Membrane activity of a C-reactive protein

Harrington, J. M., Chou, H. T., Gutsmann, T., Gelhaus, C., Stahlberg, H., Leippe, M., Armstrong, P. B.

FEBS Lett 583(6), 1001-5 (2009)

Structure determination using electron crystallography

Evans, J.E., Renault, L., Stahlberg, H.

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2dx - Automated 3D structure reconstruction from 2D crystal data

Gipson, B., Zeng, X., Stahlberg, H.

Microscopy and Microanalysis 14(Supp 2), 1290-1291 (2008)

Bridging across length scales: multi-scale ordering of supported lipid bilayers via lipoprotein self-assembly and surface patterning

Vinchurkar, M. S., Bricarello, D. A., Lagerstedt, J. O., Buban, J. P., Stahlberg, H., Oda, M. N., Voss, J. C., Parikh, A. N.

J Am Chem Soc 130(33), 11164-9 (2008)

The fold of alpha-synuclein fibrils

Vilar, M., Chou, H. T., Luhrs, T., Maji, S. K., Riek-Loher, D., Verel, R., Manning, G., Stahlberg, H., Riek, R.

Proc Natl Acad Sci U S A 105(25), 8637-42 (2008)

Low-dose aberration corrected cryo-electron microscopy of organic specimens

Evans, J. E., Hetherington, C., Kirkland, A., Chang, L. Y., Stahlberg, H., Browning, N.

Ultramicroscopy 108(12), 1636-44 (2008)

Membrane pore formation by pentraxin proteins from Limulus, the American horseshoe crab

Harrington, J. M., Chou, H. T., Gutsmann, T., Gelhaus, C., Stahlberg, H., Leippe, M., Armstrong, P. B.

Biochem J 413(2), 305-13 (2008)

Molecular electron microscopy: state of the art and current challenges

Stahlberg, H., Walz, T.

ACS Chem Biol 3(5), 268-81 (2008)

2dx_merge: data management and merging for 2D crystal images

Gipson, B., Zeng, X., Stahlberg, H.

J. Struct. Biol. 160(3), 375-384 (2007)

Editorial: Spotlight on Electron Crystallography

Hankamer, B., Glaeser, B., Stahlberg, H.

J Struct Biol 160(3), 263-264 (2007)

Three-dimensional electron microscopy of macromolecular assemblies (J. Frank), Book Review

Renault, L., Stahlberg, H.

Scanning 29(1), 37 (2007)

Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution

Runge, K. E., Evans, J. E., He, Z. Y., Gupta, S., McDonald, K. L., Stahlberg, H., Primakoff, P., Myles, D. G.

Dev Biol 304(1), 317-25 (2007)

2dx – User-friendly image processing for 2D crystals

Gipson, B., Zeng, X., Zhang, Z. Y., Stahlberg, H.

J Struct Biol 157(1), 64-72 (2007)

A maximum likelihood approach to two-dimensional crystals

Zeng, X., Stahlberg, H., Grigorieff, N.

J Struct Biol 160(3), 362-74 (2007)

Automatic lattice determination for two-dimensional crystal images

Zeng, X., Gipson, B., Zheng, Z. Y., Renault, L., Stahlberg, H.

J Struct Biol 160(3), 353-61 (2007)

Structural and kinetic studies of induced fit in xylulose kinase from Escherichia coli

Di Luccio, E., Petschacher, B., Voegtli, J., Chou, H. T., Stahlberg, H., Nidetzky, B., Wilson, D. K.

J Mol Biol 365(3), 783-98 (2007)

Electron crystallography of membrane proteins

Chou, H. T., Evans, J. E., Stahlberg, H.

Methods Mol Biol 369, 331-43 (2007)

The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MloK1 at 16 A resolution

Chiu, P. L., Pagel, M. D., Evans, J., Chou, H. T., Zeng, X., Gipson, B., Stahlberg, H., Nimigean, C. M.

Structure 15(9), 1053-64 (2007)

Avoiding charge induced drift in vitrified biological specimens through scanning transmission electron microscopy.

Nicotra, G., Chou, H.-T., Stahlberg, H., Browning, N.D.

Microscopy and Microanalysis 12(Supp. 02), 246-247 (2006)

Cryo-electron microscopy analysis of a 105 kDa protein particle: the xylulose kinase from E. coli

Chou, H.-T., di Luccio, E., Wilson, D., Stahlberg, H.

Microscopy and Microanalysis 12(Supp 2), 408-409 (2006)

A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays

Tao, L., Mogilner, A., Civelekoglu-Scholey, G., Wollman, R., Evans, J., Stahlberg, H., Scholey, J. M.

Curr Biol 16(23), 2293-302 (2006)

Double hexameric ring assembly of the type III protein translocase ATPase HrcN

Müller, S., Pozidis, C., Stone, R., Meesters, C., Chami, M., Engel, A., Economou, A., Stahlberg, H.

Mol Microbiol 61(1), 119-25 (2006)

Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans

Evans, J. E., Snow, J. J., Gunnarson, A. L., Ou, G., Stahlberg, H., McDonald, K. L., Scholey, J. M.

J Cell Biol 172(5), 663-9 (2006)

Milestones in electron crystallography

Renault, L., Chou, H. T., Chiu, P. L., Hill, R. M., Zeng, X., Gipson, B., Zhang, Z. Y., Cheng, A., Unger, V., Stahlberg, H.

J Comput Aided Mol Des 20(42193), 519-27 (2006)

Applications of Atomic Scale Scanning Transmission Electron Microscopy

Browning, N.D., Erni, R., Mitterbauer, C.J., Fu, L., Chi, M., Mehraeen, S., Herrera, M., Chou, H.-T., Stahlberg, H., Ramasse, Q.M., Ziegler, A., Nicotra, G., Arslan, I., Idrobo, J.-C., Stach, E.A., Bleiloch, A.

Microscopy and Microanalysis 12(S02), 134-135 (2006)

Testing 3-D Reconstruction Methods for Electron Tomography

Mehraeen, S., Stahlberg, H., Evans, J. E., Meesters, C., Arslan, I., Midgley, P.A., Browning, N. D.

Microscopy and Microanalysis 11(S02), 336-337 (2005)

The 4.5 Å structure of human AQP2

Schenk, A. D., Werten, P. J., Scheuring, S., de Groot, B. L., Müller, S., Stahlberg, H., Philippsen, A., Engel, A.

J Mol Biol 350(2), 278-89 (2005)

Oligomeric structure of the Bacillus subtilise cell division protein DivIVA determined by transmission electron microscopy

Stahlberg, H., Kutejova, E., Muchova, K., Gregorini, M., Lustig, A., Müller, S., Olivieri, V., Engel, A., Wilkinson, A. J., Barak, I.

Mol Microbiol 52(5), 1281-90 (2004)

Type III protein translocase: HrcN is a peripheral ATPase that is activated by oligomerization

Pozidis, C., Chalkiadaki, A., Gomez-Serrano, A., Stahlberg, H., Brown, I., Tampakaki, A. P., Lustig, A., Sianidis, G., Politou, A. S., Engel, A., Panopoulos, N. J., Mansfield, J., Pugsley, A. P., Karamanou, S., Economou, A.

J Biol Chem 278(28), 25816-24 (2003)

IPLT: An image processing library and toolkit for the electron microscopy community

Philippsen, A., Schenk, A. D., Stahlberg, H., Engel, A.

J Struct Biol 144(42006), 42106 (2003)

Progress in the analysis of membrane protein structure and function

Werten, P. J., Remigy, H. W., de Groot, B. L., Fotiadis, D., Philippsen, A., Stahlberg, H., Grubmuller, H., Engel, A.

FEBS Lett 529(1), 65-72 (2002)

Aquaglyceroporins: channel proteins with a conserved core, multiple functions, and variable surfaces

Engel, A., Stahlberg, H.

Int Rev Cytol 215, 75-104 (2002)

Sampling the conformational space of membrane protein surfaces with the AFM

Scheuring, S., Muller, D. J., Stahlberg, H., Engel, H. A., Engel, A.

Eur Biophys J 31(3), 172-8 (2002)

Assessing the structure of membrane proteins: combining different methods gives the full picture

Stahlberg, H., Engel, A., Philippsen, A.

Biochem Cell Biol 80(5), 563-8 (2002)

Charting and unzipping the surface layer of Corynebacterium glutamicum with the atomic force microscope

Scheuring, S., Stahlberg, H., Chami, M., Houssin, C., Rigaud, J. L., Engel, A.

Mol Microbiol 44(3), 675-84 (2002)

The aquaporin superfamily: structure and function

Stahlberg, H., Heymann, B., Mitsuoka, K., Fuyijoshi, Y., Engel, A.

Current Topics in Membranes 51, 39-119 (2001)

ATP synthase: constrained stoichiometry of the transmembrane rotor

Muller, D. J., Dencher, N. A., Meier, T., Dimroth, P., Suda, K., Stahlberg, H., Engel, A., Seelert, H., Matthey, U.

FEBS Lett 504(3), 219-22 (2001)

Bacterial Na(+)-ATP synthase has an undecameric rotor

Stahlberg, H., Muller, D. J., Suda, K., Fotiadis, D., Engel, A., Meier, T., Matthey, U., Dimroth, P.

EMBO Rep 2(3), 229-33 (2001)

Two-dimensional crystals: a powerful approach to assess structure, function and dynamics of membrane proteins

Stahlberg, H., Fotiadis, D., Scheuring, S., Remigy, H., Braun, T., Mitsuoka, K., Fujiyoshi, Y., Engel, A.

FEBS Lett 504(3), 166-72 (2001)

Electron Cryomicroscopy

Dubochet, J., Stahlberg, H.

eLS - Enceclopedia of Life Sciences (online library), (2001)

Conformational changes, flexibilities and intramolecular forces observed on individual proteins

Müller, D.J., Oesterhelt, F., Dencher, N., Seelert, H., Stahlberg, H., Gaub, H., Engel, A.

European Biophysics Journal 29(4), 232 (2000)

2D-crystallization and structural characterization of the chloroplast H+-ATP synthase

Seelert, H., Poetsch, A., Dencher, N.A., Kühlbrandt, W., Engel, A., Stahlberg, H., Müller, D.J.

European Biophysics Journal 29(4), 337 (2000)

The aquaporin sidedness revisited

Scheuring, S., Tittmann, P., Stahlberg, H., Ringler, P., Borgnia, M., Agre, P., Gross, H., Engel, A.

J. Mol. Biol. 299(5), 1271-1278 (2000)

GlpF: A structural variant of the aquaporin tetramer

Braun, T., Philippsen, A., Wirtz, S., Borgnia, J., Agre, P., Kühlbrandt, W., Engel, A., Stahlberg, H.

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Proton-powered turbine of a plant motor

Seelert, H., Poetsch, A., Dencher, N. A., Engel, A., Stahlberg, H., Muller, D. J.

Nature 405(6785), 418-9 (2000)

Surface tongue-and-groove contours on lens MIP facilitate cell-to-cell adherence

Fotiadis, D., Hasler, L., Muller, D. J., Stahlberg, H., Kistler, J., Engel, A.

J Mol Biol 300(4), 779-89 (2000)

The 3.7 Å projection map of the glycerol facilitator GlpF: a variant of the aquaporin tetramer

Braun, T., Philippsen, A., Wirtz, S., Borgnia, M. J., Agre, P., Kühlbrandt, W., Engel, A., Stahlberg, H.

EMBO Rep 1(2), 183-9 (2000)

The 6.9-Å structure of GlpF: a basis for homology modeling of the glycerol channel from Escherichia coli

Stahlberg, H., Braun, T., de Groot, B., Philippsen, A., Borgnia, M. J., Agre, P., Kühlbrandt, W., Engel, A.

J Struct Biol 132(2), 133-41 (2000)

Domain structure of secretin PulD revealed by limited proteolysis and electron microscopy

Nouwen, N., Stahlberg, H., Pugsley, A. P., Engel, A.

EMBO J 19(10), 2229-36 (2000)

The reaction centre from green sulphur bacteria Chlorobium tedium: a structural analysis by scanning transmission electron microscopy

Remigy, H. W., Stahlberg, H., Fotiadis, D., Müller, S., Wolpensinger, B., Engel, A., Hauska, G., Tsiotis, G.

J Mol Biol 290(4), 851-858 (1999)

Structural investigation of the major intrinsic protein of lens fiber cell membranes

Hasler, L., Fotiadis, D., Müller, D.J., Kistler, J., Engel, A., Stahlberg, H.

Biophysical Journal 76(1), A136 (1999)

Structure of the water channel AqpZ from Escherichia coli revealed by electron crystallography

Ringler, P., Borgnia, M. J., Stahlberg, H., Maloney, P. C., Agre, P., Engel, A.

J Mol Biol 291(5), 1181-90 (1999)

High resolution AFM topographs of the Escherichia coli water channel aquaporin Z

Scheuring, S., Ringler, P., Borgnia, M., Stahlberg, H., Muller, D. J., Agre, P., Engel, A.

EMBO J 18(18), 4981-7 (1999)

Mitochondrial Lon of Saccharomyces cerevisiae is a ring-shaped protease with seven flexible subunits

Stahlberg, H., Kutejova, E., Suda, K., Wolpensinger, B., Lustig, A., Schatz, G., Engel, A., Suzuki, C. K.

Proc Natl Acad Sci U S A 96(12), 6787-90 (1999)

The reaction centre of the photounit of Rhodospirillum rubrum is anchored to the light-harvesting complex with four-fold rotational disorder

Stahlberg, H., Dubochet, J., Vogel, H., Ghosh, R.

Photosynthesis Research 55, 363-368 (1998)

Are the light-harvesting I complexes from Rhodospirillum rubrum arranged around the reaction centre in a square geometry?

Stahlberg, H., Dubochet, J., Vogel, H., Ghosh, R.

J Mol Biol 282(4), 819-31 (1998)

Friction anisotropy and asymmetry of a compliant monolayer induced by a small molecular tilt

Liley, M., Gourdon, D., Stamou, D., Meseth, U., Fischer, T. M., Lautz, C., Stahlberg, H., Vogel, H., Burnham, N. A., Duschl, C.

Science 280(5361), 273-5 (1998)

Chloroplast F0F1 ATP synthase imaged by atomic force microscopy

Neff, D., Tripathi, S., Middendorf, K., Stahlberg, H., Butt, H. J., Bamberg, E., Dencher, N. A.

J Struct Biol 119(2), 139-48 (1997)

Sulphur-bearing lipids for the covalent attachment of supported lipid bilayers to gold surfaces: a detailed characterisation and analysis

Duschl, C., Liley, M., Lang, J, Ghandi, A., Zakeeruddin, S.M., Stahlberg, H., Dubochet, J., Nemetz, A., Knoll, W., Vogel, H.

Materials Science & Engineering C 4, 7-18 (1996)

2D thiolipid crystals examined by dark field transmission electron microscopy

Stahlberg, H., Duschl, C., Liley, M., Vogel, H., Dubochet, J.

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