Lukas Van Den Heuvel

About

Lukas van den Heuvel studies fibrils that are involved in neurodegenerative diseases, using cell culture models as environment to seed, generate and study specific types of fibrils. For this, he uses correlative light and electron microscopy in a collaboration between Anne-Laure Mahul-Mellier in the D'Angelo lab at the EPFL and our lab.

Current Project

Analysis of alpha-synuclein rich inclusions in human brain of Parkinson’s Disease

Biography

Lukas performed his Master Thesis in our laboratory in 2022/2023 on the structural basis of Parkinson’s Disease in the human brain. He used correlative light and electron microscopy to characterize the early stages of Lewy Body formation.

He did his undergraduate in Nanobiology at the TU Delft, the Netherlands.

Publications

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Ultrastructural diversity of alpha-Synuclein pathology in the post-mortem brain of Parkinson patients: implications for Lewy Body formation

Lewis, A., Van Den Heuvel, L., Di Fabrizio, M., Burger, D., Huisman, E., Bol, J.G.J.M., van de Berg, W.D.J., Stahlberg, H.

(submitted), (2025)

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Synthetic alpha-synuclein fibrils replicate in mice causing MSA neuropathology

Burger, D., Kashyrina, M., Van Den Heuvel, L., de la Seigliere, H., Lewis, A., De Nuccio, F., Mohammed, I., Verchère, J., Feuillie, C., et al., Lofrumento, D.D., De Giorgi, F., Stahlberg, H., Ichas, F.

(submitted), (2025)

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Correlative light and electron microscopy for human brain and other biological models

Shafiei, N., Stähli, D., Burger, D., Di Fabrizio, M., Van Den Heuvel, L., Daraspe, J., Böing, C., Shahmoradian, S., van de Berg, W.D.J., Genoud, C., Stahlberg, H., Lewis, A.

Nature Protocols (in press), (2025)

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