Massimo Kube

About

Massimo joined the LBEM in February 2024 after doing his PhD in Prof. Hendrik Dietz’s lab in Munich. During his PhD, he worked on the three-dimensional reconstruction of DNA Origami structures. His main project focussed on the development of a DNA Origami force spectrometer that allows for the reconstruction of force-sensitive proteins while a force is applied at the same time.
Continuing his journey of innovation, Massimo has now embarked on a new project at the LBEM. He is currently developing a 4D STEM workflow for biological samples under cryo-EM conditions, a project that promises to push the boundaries imposed by classical CTEM in this field.

Current Project

Development of a 4D STEM pipeline for Cryo-EM.

Biography

Education

2/2024 - presentPostDoc, Laboratory of Biological Electron Micoscopy (LBEM), Institute of Physics, EPFL, Switzerland
1/2023 - 1/2024 PostDoc, Laboratory of Bionanotechnology and Molecular Robotics at the Technical University Munich, Germany
5/2017 - 12/2022PhD Thesis, Laboratory of Bionanotechnology and Molecular Robotics at the Technical University Munich, Germany

Publications

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Phase contrast 4D-STEM tomography of thick biological specimens

Küçükoglu, B., Kube, M., c, Varnavides, G., Ribet, S.M., Stähli, D., Daraspe, J., Radecke, J., Ophus, C., Stahlberg, H.

Microscopy and Microanalysis 31(Suppl. 1), ozaf048.1126 (2025)

DOI: DOI

3

Low-dose cryo-electron ptychography of proteins at sub-nanometer resolution

Küçükoglu, B., Mohammed, I., Guerrero Ferreira, R., Kube, M., Radecke, J., Ribet, S.M., Varnavides, G., Leidl, M.L., Lau, K., Nazarov, S., Myasnikov, A., Sachse, C., Müller-Caspary, K., Ophus, C., Stahlberg, H.

Nature Communications 15, 8062 (2024)

DOI: DOI

2

Progress in Physics: Structural analysis of proteins by cryo-electron ptychography

Küçükoglu, B., Kube, M., Stahlberg, H.

SPS Communications 73, 34-37 (2024)

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